For many of my patients, this is manifest as migraine headaches. Migraine is one of the most common diseases in the world, more prevalent than diabetes and asthma combined, and the direct and indirect cost of migraine in Canada has been estimated at more than $700 million annually. Particularly incapacitating is chronic migraine, which is a throbbing, debilitating headache that can last 15 or more days a month. Can you imagine living with a painful headache most of your life?